structure of colistin, 1 of few antibiotics able treat ndm-1 positive bacterial infections.
in july 2010, team in new delhi reported cluster of 3 cases of acinetobacter baumannii bearing blandm-1 found in intensive care unit of hospital in chennai, india, in april 2010. previously, bacteria resistant aminoglycoside β-lactam , quinolone antibiotics, susceptible tigecycline , colistin. particularly broad spectrum of antibiotic resistance heightened strain s expressing several different resistance genes in addition blandm-1.
a study multi-national team published in august 2010 issue of journal lancet infectious diseases. examined emergence , spread of bacteria carrying blandm-1 gene. reported on 37 cases in united kingdom, 44 isolates ndm-1in chennai, 26 in haryana, , 73 in various other sites in pakistan , india. authors analysis of strains showed many carried blandm-1 on plasmids, allow gene readily transferred between different strains of bacteria horizontal gene transfer. isolates resistant multiple different classes of antibiotics, including beta-lactam antibiotics, fluoroquinolones, , aminoglycosides, still susceptible polymyxin antibiotic colistin.
on 21 august 2010, ontario, canada, had first confirmed case of superbug in brampton. there other confirmed cases in british columbia , alberta. these confirmed ndm-1 infected cases have no relationship new delhi, india. patients or relatives never travelled india in last decade.
in august 2010, chemical compound gsk 299423 found fight against antibiotic-resistant bacteria making such bacteria unable reproduce, citing treatment ndm-1 strain.
on 6 september 2010, japan detected first ever case of ndm-1 enzyme. in may 2009, japanese man in 50s had returned vacation in india struck fever , hospitalized, later making full recovery. hospital officials confirmed tests carried out after patient s recovery positive ndm-1 enzyme.
an environmental point prevalence study conducted between 26 september , 10 october 2010 found bacteria ndm-1 gene in drinking water , seepage samples in new delhi. 50 tap water samples , 171 seepage samples collected sites within 12 km of central new delhi. of these samples, 20 strains of bacteria found contain ndm-1 gene in 51 out of 171 seepage samples , 2 out of 50 tap water samples.
on 8 may 2012, presence of ndm found in patient died @ royal alexandra hospital in edmonton, alberta. patient found carrying acinetobacter strain. patient contracted bacteria after patient, had surgery on indian subcontinent, traveled canada , admitted hospital infection.
science daily reported on 16 december 2013 team of scientists rice, nankai , tianjin universities found ndm-1 in 2 wastewater treatment plants in northern china.
in june 2014 reported molecule aspergillomarasmine aspergillus fungus turns off resistance mechanism of ndm-1 , makes bacteria once again sensitive traditional antibiotics. has been shown effective in mice , rats has not yet been tested in humans safety or effectiveness.
in september 2016, 70-year-old woman in reno, nevada, died of septic shock following infection ndm-producing klebsiella pneumoniae. had been on extended trip india , admitted hospital there infected right hip.
Comments
Post a Comment