Genetic_structure_and_related_subtypes Influenza_A_virus_subtype_H5N1

the n in h5n1 stands neuraminidase , protein depicted in ribbon diagram.

h5n1 subtype of species influenza virus of influenzavirus genus of orthomyxoviridae family. other influenza subtypes, h5n1 subtype rna virus. has segmented genome of 8 negative sense, single-strands of rna, abbreviated pb2, pb1, pa, ha, np, na, mp , ns.

ha codes hemagglutinin, antigenic glycoprotein found on surface of influenza viruses , responsible binding virus cell being infected. na codes neuraminidase, antigenic glycosylated enzyme found on surface of influenza viruses. facilitates release of progeny viruses infected cells. hemagglutinin (ha) , neuraminidase (na) rna strands specify structure of proteins medically relevant targets antiviral drugs , antibodies. ha , na used basis naming of different subtypes of influenza viruses. h , n come in h5n1.

influenza viruses significant potential disease , death in humans , other animals. influenza virus subtypes have been confirmed in humans, in order of number of known human pandemic deaths have caused, include:

h1n1, caused 1918 flu pandemic ( spanish flu ) , causing seasonal human flu , 2009 flu pandemic ( swine flu )
h2n2, caused asian flu
h3n2, caused hong kong flu , causes seasonal human flu
h5n1, ( bird flu ), noted having strain (asian-lineage hpai h5n1) kills on half humans infects, infecting , killing species never known suffer influenza viruses before (e.g. cats), being unable stopped culling involved poultry - think due being endemic in wild birds, , causing billions of dollars spent in flu pandemic preparation , preventiveness
h7n7, has unusual zoonotic potential , killed 1 person
h1n2, endemic in humans , pigs , causes seasonal human flu
h9n2, has infected 3 people
h7n2, has infected 2 people
h7n3, has infected 2 people
h10n7, has infected 2 people
h7n9, of feb 2014 has infected 309 people, , lead 70 deaths




^ couch, r. (1996). chapter 58. orthomyxoviruses multiplication . in baron, s. medical microbiology. galveston, texas: university of texas medical branch @ galveston. isbn 0-9631172-1-1.