there no highly effective treatment h5n1 flu, oseltamivir (commercially marketed roche tamiflu), can inhibit influenza virus spreading inside user s body. drug has become focus governments , organizations trying prepare possible h5n1 pandemic. on april 20, 2006, roche ag announced stockpile of 3 million treatment courses of tamiflu waiting @ disposal of world health organization used in case of flu pandemic; separately roche donated 2 million courses use in developing nations may affected such pandemic lack ability purchase large quantities of drug.
however, expert hassan al-bushra has said:
now, remain unsure tamiflu s real effectiveness. vaccine, work cannot start on until emergence of new virus, , predict take 6 9 months develop it. moment, cannot means count on potential vaccine prevent spread of contagious influenza virus, various precedents in past 90 years have been highly pathogenic .
animal , lab studies suggest relenza (zanamivir), in same class of drugs tamiflu, may effective against h5n1. in study performed on mice in 2000, zanamivir shown efficacious in treating avian influenza viruses h9n2, h6n1, , h5n1 transmissible mammals . in addition, mice studies suggest combination of zanamivir, celecoxib , mesalazine looks promising producing 50% survival rate compared no survival in placebo arm. while no 1 knows if zanamivir useful or not on yet exist pandemic strain of h5n1, might useful stockpile zanamivir oseltamivir in event of h5n1 influenza pandemic. neither oseltamivir nor zanamivir can manufactured in quantities meaningful once efficient human transmission starts. in september, 2006, scientist announced studies had confirmed cases of h5n1 strains resistant tamiflu , amantadine. tamiflu-resistant strains have appeared in eu, remain sensitive relenza.
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