thyroid niftp tumor capsule
there no evidence of invasion of formed fibrous connective tissue capsule, helping support diagnosis of niftp.
niftp tumor shows specific nuclear features of papillary thyroid carcinoma.
the nuclear features of papillary thyroid carcinoma, within encapsulated neoplasm: niftp
several specific features must identified tumor classified in new category, while exclusion criteria should evaluated.
1) encapsulated or partially encapsulated. tumors delimited or circumscribed, majority encapsulated, surrounded formed fibrous connective tissue capsule.
2) complete absence of invasion of kind in tumor has been thoroughly , evaluated whole capsule of lesion sampled.
3) predominantly follicular pattern of growth. papillary structures should not present. further, solid, insular, or trabecular architecture must <30% of overall tumor category still apply. colloid (the material thyroid follicular cells create) identified throughout.
4) must have characteristic nuclear features of papillary thyroid carcinoma, although features patchy in distribution without of tumor showing features. nuclear features can divided 3 main categories:
nuclear size , shape: nuclear enlargement, nuclear elongation, , nuclear overlapping , crowding. loss of nuclear polarity, nuclei @ lumen, middle, or basal zone of cells helpful finding.
nuclear membrane irregularities: irregular nuclear contours, nuclear grooves , folds, rat-bites or demi-lune formations, , presence of intranuclear cytoplasmic inclusions.
nuclear chromatin characteristics: nuclear chromatin clearing, condensation or margination along nuclear membranes, resulting in accentuated nuclear margins, glassy nuclei, or fine, delicate, powdery nuclear chromatin.
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