Enzyme_function New_Delhi_metallo-beta-lactamase_1

structure of carbapenem backbone.

carbapenems class of beta-lactam antibiotics capable of killing bacteria inhibiting synthesis of 1 of cell wall layers. carbapenems developed overcome antibiotic resistance mediated bacterial beta-lactamase enzymes. however, blandm-1 gene produces ndm-1, carbapenemase beta-lactamase - enzyme hydrolyzes , inactivates these carbapenem antibiotics.

carbapenemases particularly dangerous resistance mechanisms, since can inactivate wide range of different antibiotics. ndm-1 enzyme 1 of class b metallo-beta-lactamase; other types of carbapenemase class or class d beta-lactamases. (the class klebsiella pneumoniae carbapenemase (kpc) common carbapenemase, first detected in north carolina, united states, in 1996 , has since spread worldwide. later publication indicated enterobacteriaceae produce kpc becoming common in united states.)

the resistance conferred gene (blandm-1), therefore, aids expansion of bacteria carry throughout human host, since face less opposition/competition populations of antibiotic-sensitive bacteria, diminished original antibacterial treatment.